Bio-Process Intensification

Biopharmaceutical Process Intensification (PI)
Biopharmaceutical Process Intensification (PI)
See additional information about 4C continuousSee additional information about 4C continuous
See additional description about RTF Integrated processSee additional description about RTF Integrated process
See additional description about CBMSSee additional description about CBMS
Process columns and packing stationProcess columns and packing station
Chromatography SystemsChromatography Systems
Find out Lisure's SolutionFind out Lisure's Solution
TFF/NFF filtration systems And Custom EngineeringTFF/NFF filtration systems And Custom Engineering
Lab ProductsLab Products
Accessaries and partsAccessaries and parts
Inline Dilution/Conditioning systemsInline Dilution/Conditioning systems

FIRST OF ALL

Continuous Buffer Prep/Management System (CBMS)

Just as video streaming revolutionized how we play video, we have an inline-mixing/relay-tank based buffer prep solution with much smaller footprint. The small footprint and full S88 operation solution of the solution led to significant capital saving, operational saving, and better documentation. This unique process concept can be applied with either Single Use or Stainless Steel vessels for not only green field but also brown field projects. Attributed to innovative development in standardizing the functional modules and control strategies of the system, CBMS is a robust alternative to traditional tank farm for buffer prep area. The modular CBMS can be aligned to existing facility and has a S88 batch operation solution for multi-units on DCS platform.

CBMS - a group of equipment unit in a factory
CBMS - a group of equipment unit in a factory
  • Significant Saving On Capex

  • Lower Operating Cost

  • Reduced Cycle Time

  • Much Smaller Footprint

  • S88 Batch Automation

  • Better Documentation

Inline dilution/conditioning chromatography system
Inline dilution/conditioning chromatography system

OUR STORY

Inline Dilution/Conditioning Process Chromatography (ICPC)

Trust Lisure Technology Co. to simplify your bioprocess. ICPC combines buffer prep and process chromatography in one step leading to significant capital and operational saving through its small footprint. Lisure ICPC achieves high dilution ratio through its patented mixing flow chamber design and a relay tank for critical buffer. Lisure's patented internal recirculation loop for each concentrate stream minimizes the buffer waste during system stabilization. The system has a DCS based process control strategy and can be easily integrated with plant DCS.

  • Chrom&Buffer Combined

  • Small Footprint

  • Minimized Buffer Waste

  • High Dilution Ratio

  • Chrom Artifacts Avoided

Axi-compression acrylic tube chromatography column
Axi-compression acrylic tube chromatography column

OUR STORY

Chromatography Columns For Scaleup Performance

Discover how Lisure Technology Co. revolutionizes the biopharmaceutical industry with our innovative process solutions. Columns do not have to be scaled wide anymore even for compressible media. Wall effect used to be a myth for columns larger than 300mm but not anymore. With superior HETP from newly designed bed-independent flow distributor, chromatography columns can now be scaled up with higher bed height and same residence time (RT). Therefore much smaller columns can achieve the same productivity as large wide columns could, reducing capital investment significantly.

  • Larger Column with Lower Bed

  • No Wall Effect @>300mm

  • Higher Bed for Soft Media

  • Better Efficiency (HETP)

  • Higher DBC/Less Media

OUR STORY

Integrated Downstream Process - Radial Tangential Flow (RTF) Chromatography

Find out our cutting-edge process solutions that streamline biopharmaceutical downstream processes, making them simpler and more efficient. We have combined centrifuge, depth filtration, and capture chromatography all in one elegant step. This would not be possible without several key developments: Non-clogging RTF column with high efficiency HETP, Continuous foulant filter guard, Self-enclosed recirculation, and its novel process configuration. The economical and operational benefits can not be more obvious: less capital, fewer processing steps, shorter cycle time, higher resin binding capacity, no depth filters, and fully automated.

Continuous Capture Chromatography System
Continuous Capture Chromatography System
  • One Step Integrating Three

  • Completely Enclosed Process

  • Shorter Cycle Time

  • Significant Benefits

  • Better HETP

  • Higher DBC/Less Media

OUR STORY

4C Continuous Chromatography On DCS

We made 4C continuous chromatography easy. Continuous chromatography achieves efficient and cost-saving scale-up with smaller columns and better utilization of resin. It used to be complicated to implement but we have designed specialized valve matrix and a control strategy, DCS based control solution, all ready to go

  • Higher DBC/Less Media

  • Reduced Total Cycle Time

  • Smaller Column & System

  • S88 Batch Automation

Proof Of Concept: Pilot Scale Multi-Functional PD/TT System

Please check in with us for Lisure APPS Pilot SuperPlus system. Lisure Pilot SuperPlus is an ultimate process development and tech transfer tool geared towards cGMP environment and production operation for biopharmaceutical downstream processing. It has a cGMP compliant hygienic flow path design and DeltaV DCS/S88 Industrial control solution. Flow rate goes up to 750ml/min at 6 bar. It is a versatile flow handling system that is ready for running Chromatography, Inline dilution, TFF filtration, NFF filtration, as well as many process intensification configurations such as 2C Alternating Continuous Chromatography, Columns In Series, 3C/4C Multi-Column Continuous Chromatography, Continuous NFF filtration, and Radial Tangential Flow (RTF) Integrated Process. The system features a flexible and modular design that allows customers to add on additional functions as they need. With Lisure's Pilot SuperPlus, customers can easily figure out what is their best process intensification strategy and achieve the fastest proof of concept (POC). Lisure APPS SuperPlus streamlines drug development pipeline with its introduction of DCS and S88 batch management concept to pilot and tech transfer and is well aligned with the digital transformation trend in the industry.

  • cGMP Hygienic Flowpath

  • Standard Chrom System

  • RTF Integrated Process

  • Standard TFF System

  • DeltaV DCS/Batch Control

  • Columns in Series

  • 2C Continuous Chrom

  • 3C/4C Continuous Chrom

  • Continuous NFF Filtration

  • 750 ml/min @ 6bar

OUR STORY

Single Use Chromatography System

Discover how Lisure Technology Co. revolutionizes the biopharmaceutical industry with our innovative process solutions. Columns do not have to be scaled wide anymore even for compressible media. Wall effect used to be a myth for columns larger than 300mm but not anymore. With superior HETP from newly designed bed-independent flow distributor, chromatography columns can now be scaled up with higher bed height and same residence time (RT). Therefore much smaller columns can achieve the same productivity as large wide columns could, reducing capital investment significantly.

OUR STORY

And let's not forget

Custom Engineering And S88 Batch Automation Solution

Our team of passionate scientists and engineers, combined with experienced bioprocess solution professionals, ensures the highest quality and efficiency in building customized downstream process solutions. With our key technical competency in flow system design, high-end hardware design, control strategy design, and quality management, we provide top-notch bioprocess solutions for customers in the cGMP regulated industry. Our extensive project execution experience ensures the successful implementation of our solutions. Beyond ISO9001 certification, our adherence to industrial standards, including ASME BPE, GAMP, and ISA S88, reflects our unwavering commitment to excellence. Let us be the driving force behind your success in navigating custom engineering challenges in bioprocessing.

Transforming Biopharmaceutical Downstream Process

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